In the second derashah of Derashos haRan, the Ran discusses the adversarial relationship between Yaakov and Eisav / Edom, Yitzchaq praying for Rivqa to become pregnant becomes a discussion of how prayer effects change, and the Ran addresses the relationship between prophecy, free will, and how changable is the future.
In this opening shiur on the derashah, we only discuss the first topic — why does Edom hate us so much?
The text is available on Sefaria, beginning at https://www.sefaria.org/Derashot_HaRan.2.1
Derashos haRan is an explanation of the fundamentals of the Torah as explicated from texts in the Chumash. The second derashah addresses parashah Toledos — Yaaqov, Eisav / Edom, antisemitism, and the natures of both prophecy and the future.